|Tested species reactivity||Guinea pig, Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Extracellular domain of human p75NTR.|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||1-5 µg/ml|
|Western Blot (WB)||1-5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-18401 detects p75NTR from human, mouse, rat, and Guinea Pig samples.
MA1-18401 has been successfully used in immunohistochemistry, immunofluorescence, flow cytometry and Western blot procedures.
The MA1-18401 immunogen is the extracellular domain of human p75NTR.
This product is not recommended for denaturing WB applications or paraffin embedded tissues.
After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid freeze/thaw cycles.
Reconstitute with 100 ul of distilled water.
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.