This antibody is predicted to react with Rhesus monkey, mouse, rat, bovine, equine and chicken based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
NIK, also known as mitogen-activated protein kinase kinase kinase (MAP3K) 14 is an NF-kappaB inducing protein kinase of the serine/threonine kinase family. NIK binds to Traf2 to activate NF-kappaB as part of a signaling cascade involving receptors of the TNF/NGF family and the interleukin-1 type-I receptor. NIK protein is shuttled between cytosolic, nuclear and nucleolar compartments. When shuttled to the nucleoli, NIK-dependant NF-kappaB activation is impaired relative to its nuclear localization revealing a possible means of regulation. Reactive oxygen species can interact directly with NIK to alter NF-kappaB activation. Additionally, NIK specifically interacts with Down syndrome candidate region 1 (DSCR1) blocking its proteosomal degradation leading to DSCR1 accumulation and cytotoxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FTDCR1B; HS; HSNIK; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK; serine/threonine protein-kinase; Serine/threonine-protein kinase NIK
Gene Aliases: FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558
Entrez Gene ID: (Human) 9020