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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A peptide corresponding to amino acids 931 to 947 of human NIK.|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is 293 cell lysate.
PA5-19871 can be used with blocking peptide PEP-0007.
Nuclear factor kappa B (NF-kappa-B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-a, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kappa-B activation by IL-1, TNF-a and CD95 was identified recently and designated NIK (for NF-kappa-B inducing kinase). NIK is an activator of Ikappa-B kinase alpha and beta (IKK-a and IKK-b). Therefore, NIK is a key molecule in the NF-kappa-B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
FTDCR1B, HS, HSNIK, NIK; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK
FTDCR1B; HS; HSNIK; MAP3K14; NIK