|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Mouse NK Cells (NK1.1)|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1.0 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17977 targets NK Cells/NK1.1 in FACS applications and shows reactivity with Mouse samples.
The MA5-17977 immunogen is mouse NK Cells (NK1.1).
Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Lung epithelial cells are essential effectors of inducible resistance to pneumonia.
MA5-17977 was used in blocking or activating experiment to study inducible resistance to infectious pneumonia and the role played by pulmonary epithelial cells
|Cleaver JO,You D,Michaud DR,Pruneda FA,Juarez MM,Zhang J,Weill PM,Adachi R,Gong L,Moghaddam SJ,Poynter ME,Tuvim MJ,Evans SE||Mucosal immunology (7:78)||2014|
|Not Applicable||Not Cited||
Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin.
MA5-17977 was used in flow cytometry to elucidate the role of VAMP8 in the thymus
|Kanwar N,Fayyazi A,Backofen B,Nitsche M,Dressel R,von Mollard GF||Cell and tissue research (334:227)||2008|
Induction of B-cell tolerance by retroviral gene therapy.
MA5-17977 was used in flow cytometry to study tolerance to alphaGal.
|Bracy JL,Iacomini J||Blood (96:3008)||2000|