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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 129 and 191 of Human NKIRAS2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29432 targets NKIRAS2 in IF and WB applications and shows reactivity with Human samples.
The PA5-29432 immunogen is synthetic peptide corresponding to a region within amino acids 129 and 191 of Human NKIRAS2.
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
I-kappa-B-interacting Ras-like protein 2; kappa B-Ras protein 2; kappaB-Ras2; KBRAS2; NFKB inhibitor interacting Ras-like 2; NFKB inhibitor interacting Ras-like protein 2
kappaB-Ras2; KBRAS2; NKIRAS2