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|Tested species reactivity||Rat|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Rat 24.5 kD cell surface protein known as NKR-P1|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||5 µL/sample|
|Immunohistochemistry (IHC)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MANK07 targets NKR-P1 in FACS, and IHC applications and shows reactivity with Rat samples.
The MANK07 immunogen is rat 24.5 kD cell surface protein known as NKR-P1.
MANK07 detects NKR-P1 which has a predicted molecular weight of approximately 25 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.
MANK07 was used in immunocytochemistry to study the role of PAR activation in vivo to initiate MCP-dependent leukocyte recruitment
|Chen D,Carpenter A,Abrahams J,Chambers RC,Lechler RI,McVey JH,Dorling A||The Journal of experimental medicine (205:1739)||2008|
A transmembrane-anchored rat RAE-1-like transcript as a ligand for NKR-P2, the rat ortholog of human and mouse NKG2D.
MANK07 was used in flow cytometry to identify the ligand for the rat ortholog of human and mouse NKG2D
|Savithri B,Khar A||European journal of immunology (36:107)||2006|
Target cell induced activation of NK cells in vitro: cytokine production and enhancement of cytotoxic function.
MANK07 was used in flow cytometry to investigate the changes of cytokine expression in NK cells after interacting with tumor cells
|Das S,Varalakshmi C,Kumari AL,Patel M,Khar A||Cancer immunology, immunotherapy : CII (50:428)||2001|
Interleukin-2-induced nitric oxide synthase and nuclear factor-kappaB activity in activated natural killer cells and the production of interferon-gamma.
MANK07 was used in flow cytometry to investigate the role of interleukin 2 in the regulation of natural killer cell function
|Jyothi MD,Khar A||Scandinavian journal of immunology (52:148)||2000|
Target-cell-induced anergy in natural killer cells: suppression of cytotoxic function.
MANK07 was used in flow cytometry to investigate the cytotoxic functions of natural killer cells
|Das S,Varalakshmi C,Khar A||Cancer immunology, immunotherapy : CII (49:109)||2000|
Lymphocyte subpopulations in lymphoid organs of rats after acute resistance exercise.
MANK07 was used in flow cytometry to investigate the changes of lymphocyte subpopulations in vivo with acute resistance exercise
|Mastro AM,Schlosser DA,Grove DS,Lincoski C,Pishak SA,Gordon S,Kraemer WJ||Medicine and science in sports and exercise (31:74)||1999|
Administration of anti-IL-12 antibody in vivo inhibits rejection of a rat histiocytoma and suppresses cytokine response in a tumour-bearing host.
MANK07 was used in flow cytometry to investigate the effect of interleukin 12 inhibition on tumor rejection
|Rao KL,Varalakshmi C,Ali AM,Khar A||Immunology (92:381)||1997|
Natural killer cell activation-associated induction of target cell DNA fragmentation in a spontaneously regressing rat histiocytoma.
MANK07 was used in flow cytometry to investigate the effect of natural killer cells on apoptosis in a regressing histiocytoma
|Bright JJ,Kausalya S,Khar A||Immunology (85:638)||1995|
Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells.
MANK07 was used in immunohistochemistry to study the mechanism for the suicide gene therapy of ovary tumors
|Nagy HJ,Panis Y,Fabre M,Engelmann C,Soubrane O,Houssin D,Klatzmann D||Biomedicine & pharmacotherapy = Biome¿decine & pharmacothe¿rapie (54:479)||2000|
Eradication of rat malignant gliomas by retroviral-mediated, in vivo delivery of the interleukin 4 gene.
MANK07 was used in immunohistochemistry to evaluate the interleukin 4 gene therapy of rat malignant gliomas
|Benedetti S,Bruzzone MG,Pollo B,DiMeco F,Magrassi L,Pirola B,Cirenei N,Colombo MP,Finocchiaro G||Cancer research (59:645)||1999|
Phospholipase A2-mediated inflammation induces regression of malignant gliomas.
MANK07 was used in immunohistochemistry to investigate the effect of phospholipase A2 on glioma inhibition in vivo
|Goddard DH,Bomalaski JS,Lipper S,Shorr RG,Clark MA||Cancer letters (102:1)||1996|
Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers.
MANK07 was used in immunohistochemistry to study the role of mitochondrial pathway in neutrophil survival modulated by IgE in asthma
|Vukanovic J,Isaacs JT||Cancer research (55:1499)||1995|
antigen 3.2.3; CD161 antigen-like family member A; killer cell lectin-like receptor subfamily B member 1A; natural killer cell surface protein P1-3.2.3; NKR-P1 3.2.3
Klrb1a; NKR-P1A; Nkrp1a