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NeoBiotechnologies

NKX3.1 Recombinant Rabbit Monoclonal Antibody (NKX3.1, 4562R)

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NKX3.1 Recombinant Rabbit Monoclonal Antibody (NKX3.1, 4562R)

Product Details

4824-RBM12-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

NKX3.1, 4562R

Immunogen

Recombinant fragment (around aa 92-224) of human NKX3.1 protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Antibody is tested in direct ELISA.

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeobox protein NK-3 homolog A; NK homeobox, family 3, A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3-1 antibody; prostate-specific ag

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Gene Aliases: BAPX2; NKX3; NKX3.1; NKX3A

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UniProt ID: (Human) Q99801

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Entrez Gene ID: (Human) 4824

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding cysteine-type endopeptidase activator activity involved in apoptotic process estrogen receptor binding histone deacetylase binding sequence-specific DNA binding MADS box domain binding DNA-binding transcription factor binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter urogenital system development metanephros development somitogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus salivary gland development heart development positive regulation of cell proliferation male gonad development regulation of signal transduction positive regulation of gene expression negative regulation of gene expression cell differentiation androgen receptor signaling pathway prostate gland development regulation of protein localization response to testosterone response to lipid dorsal aorta development regulation of cell proliferation negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter branching morphogenesis of an epithelial tube negative regulation of epithelial cell proliferation regulation of multicellular organismal process positive regulation of cell division positive regulation of protein kinase B signaling pharyngeal system development branching involved in prostate gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to steroid hormone stimulus cellular response to hypoxia cellular response to xenobiotic stimulus positive regulation of androgen secretion positive regulation of intrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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