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Product Details
PA5-68214
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human NKX6-2.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2691988
Product Specific Information
Predicted to react with Human, Mouse, and Rat samples.
Target Information
Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Drosophila NK transcription factor related, gene family 6, locus 2; glial and testis specific homeobox; glial and testis-specific homeobox protein; homeobox 6B; Homeobox protein NK-6 homolog B; Homeobox protein Nkx-6.2; NK homeobox family 6, B; NK6 transcription factor related, locus 2
Gene Aliases: GTX; NKX6-2; NKX6.2; NKX6B
UniProt ID: (Human) Q9C056
Entrez Gene ID: (Human) 84504, (Mouse) 14912, (Rat) 309095
Molecular Function:
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of cell fate commitment
positive regulation of cell fate commitment
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
central nervous system myelination
endocrine pancreas development
negative regulation of glial cell differentiation
positive regulation of glial cell differentiation
neuromuscular process controlling balance
transcription from RNA polymerase II promoter
cell differentiation
oligodendrocyte differentiation
Performance Guarantee
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