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Invitrogen
NKp46 Recombinant Mouse Monoclonal Antibody (K94064_6H6)
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FIGURE: 1 / 1
NKp46 Antibody (MA564502) in IHC (P)
Immunohistochemistry (Paraffin) analysis of NKp46 in formalin-fixed paraffin-embedded tonsil tissue. Samples were incubated with NKp46 recombinant monoclonal (Product # MA564502) using a dilution of 5 µg/mL at room temperature for 1 hr followed by Poly-peroxidase conjugated goat anti-mouse IgG. Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous... View More
Product Details
MA564502
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
K94064_6H6
Immunogen
Recombinant human NCR1 (aa 31-120).
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM
Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 61%, Pig - 61%, Cynomolgus monkey - 84%.
Target Information
CD335, also known as NKp46 or NCR1, is a member of the natural cytotoxicity receptor family, which includes NKp30 and NKp44. This type I transmembrane glycoprotein is expressed on NK cells and plays a crucial role in activating and expanding resting NK cells through interactions with dendritic cells. CD335 enhances the ability of NK cells to eliminate tumor and virus-infected cells, such as those infected by influenza. CD335 consists of two Ig-like domains and is related to leukocyte immunoglobulin-like receptors (LIR) and killer inhibitory receptors (KIR). It contributes to the increased efficiency of activated NK cells in mediating tumor cell lysis. Additionally, CD335 interacts with pancreatic beta cells during the development of type 1 diabetes, highlighting its involvement in both immune defense and autoimmune processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-Mar; CD335; hNKp46; Ly-94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; NK cell-activating receptor; NK-p46
Gene Aliases: CD335; LY94; NCR1; NK-p46; NKP46
UniProt ID: (Human) O76036
Entrez Gene ID: (Human) 9437
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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