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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 454 and 675 of Human NLRP7|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-31784 targets NLRP7 in WB applications and shows reactivity with Human samples.
The PA5-31784 immunogen is recombinant fragment corresponding to a region within amino acids 454 and 675 of Human NLRP7.
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLR19.4; HYDM; leucine rich repeat and PYD containing 7; LRR and PYD containing protein 7; LRR and PYD domains-containing protein 7; NACHT; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NALP7; NLR family, pyrin domain containing 7; NOD12; nucleotide-binding oligomeri; nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; PYRIN-containing Apaf1-like protein 3
CLR19.4; HYDM; NALP7; NLRP7; NOD12; PAN7; PYPAF3