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|Tested species reactivity||Dog , Human , Rat , Primate|
|Published species reactivity||Rat , Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||NMDA receptor 2B fusion protein|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1.0-5 ug/ml|
|Immunohistochemistry (Frozen) (IHC (F))||5-10 ug/ml|
|Western Blot (WB)||1-5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.
||O'Donnell LA,Agrawal A,Jordan-Sciutto KL,Dichter MA,Lynch DR,Kolson DL||The Journal of neuroscience : the official journal of the Society for Neuroscience (26:981)||2006|
Stable expression and characterization of recombinant human heteromeric N-methyl-D-aspartate receptor subtypes NMDAR1A/2A and NMDAR1A/2B in mammalian cells.
||Varney MA,Jachec C,Deal C,Hess SD,Daggett LP,Skvoretz R,Urcan M,Morrison JH,Moran T,Johnson EC,Veliçelebi G||The Journal of pharmacology and experimental therapeutics (279:367)||1996|
NMDAR2B, MRD6, NR2B, hNR3, GluN2B
N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 2B, NMDAR2B, NR2B, glutamate [NMDA] receptor subunit epsilon-2, N-methyl-D-aspartate receptor subunit 3, NR3, glutamate receptor ionotropic, NMDA 2B, glutamate receptor subunit epsilon-2, glutamate receptor, ionotropic, NMDA2B, Glutamate [NMDA] receptor subunit epsilon 2 precursor, GRIN2B, hNR3, N-methyl-D-aspartate receptor subtype 2B, NMDE2, NME2