|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Fusion protein from the C-terminal region of the NR2A subunit of rat GRIN2A|
|Storage buffer||0.1M HEPES, pH 7.5, with 50% glycerol, 0.15M NaCl, 0.1mg/ml BSA|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||6ul per 200ug lysate|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-35377 will not cross-react with NR2B and NR2C subunits.
This antibody contains enough material to conduct 10 mini-Western blots.
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.