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|Tested species reactivity||Mouse , Rat , Human|
|Published species reactivity||Rat , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Raised against a fusion protein containing amino acid residues 25-130 of the N-terminal region of rat brain 2C subunit; this antibody recognizes the 140,000-dalton 2C subunit, as well as the 180,000-dalton 2A and 2B subunits from rat, mouse or human.|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 4 publications below|
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice.
A-6474 was used in western blot to investigate how the loss of Mecp2 disrupts function in the murine medial prefrontal cortex using acute brain slices and behavioral testing.
|Sceniak MP,Lang M,Enomoto AC,James Howell C,Hermes DJ,Katz DM||Cerebral cortex (New York, N.Y. : 1991) (26:1938)||2016|
Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice.
A-6474 was used in western blot to study the effect of copper exposure on memory
|Ma Q,Ying M,Sui X,Zhang H,Huang H,Yang L,Huang X,Zhuang Z,Liu J,Yang X||Journal of Alzheimer's disease : JAD (43:1413)||2014|
PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors.
A-6474 was used in immunocytochemistry and western blot to study the roles of the NR2A and NR2B subunits, and of their scaffolding proteins, in remodeling the dendritic architecture of developing hippocampal neurons
|Bustos FJ,Varela-Nallar L,Campos M,Henriquez B,Phillips M,Opazo C,Aguayo LG,Montecino M,Constantine-Paton M,Inestrosa NC,van Zundert B||PloS one (9:null)||2014|
Subunit-specific modulation of [(3)H]MK-801 binding to NMDA receptors mediated by dopamine receptor ligands in rodent brain.
A-6474 was used in western blot to identify DR ligands that directly modulate NMDARs.
|Wigestrand MB,Fonnum F,Ivar Walaas S||Neurochemistry international (61:266)||2012|
AW490526, NMDAR2B, MRD6, NR2B, Nmdar2b, hNR3, GluN2B
N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR3, glutamate [NMDA] receptor subunit epsilon-2, glutamate receptor ionotropic, NMDA 2B, glutamate receptor subunit epsilon-2, GluRepsilon2, N-methyl D-aspartate receptor 2B, NMDAR2B, NR2B, glutamate receptor, ionotropic, NMDA2B, Glutamate [NMDA] receptor subunit epsilon 2 precursor, GRIN2B, hNR3, N-methyl-D-aspartate receptor subtype 2B, NMDE2, NME2