The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
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Protein Aliases: GluN2C; GluRepsilon3; Glutamate [NMDA] receptor subunit epsilon-3; Glutamate NMDA receptor subunit epsilon-3; Glutamate receptor ionotropic NMDA 2C; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; Grin2c; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; N-Methyl-D-Aspartate Receptor Type 2C; NMDA glutamate receptor; NMDAR2C; NR2C
Gene Aliases: GluN2C; GRIN2C; NMDAR2C; NR2C