This antibody specifically recognizes the ~103 kDa NMDAR1 protein. Cross-reactivity with other NMDA receptor proteins has not been observed.
N-methyl-D-aspartate (NMDA) type receptors are glutamate-gated ion channels that possess high-calcium permeability and voltage-dependent sensitivity to magnesium, and play a central role in brain function and disease. Activation of NMDA receptors, in the presence of NMDA, glutamate, and glycine, leads to elevations in synaptic calcium levels, initiating a series of calcium-dependent signaling events including activation of nitric oxide synthase, stimulation of calcium/calmodulin-dependent protein kinase, and MAP kinase cascades. Through these signal transduction pathways, NMDA receptors mediate synaptic plasticity, synaptogenesis, excitotoxicity, and memory acquisition and learning. NMDA receptors are composed of multiple subunits. The subunits are thought to coassemble in different combinations to form functionally distinct NMDA receptors. All receptors contain an NR1 subunit and various numbers of NR2 subunits. NR2b is the major subunit expressed in adult forebrain. NR2 is also a major component of the postsynaptic density in hippocampus and cerebral cortex. The NR1 subunit is encoded by a single gene, which undergoes extensive alternative splicing to generate eight different splice forms. The NR2 subunit class consists of four genes encoding the subunits NR2A-NR2D. In addition to mediating diverse aspects of synaptic physiology, NMDA receptors also play a major role in neurodegenerative diseases. Overactivity of NMDA receptors is implicated in numerous neurodegenerative processes including stroke, Alzheimer's disease, Huntington's chorea, and amyotrophic lateral sclerosis. NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning.
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Protein Aliases: GluN1; GLURZ1; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta 1 precursor; Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDZ1; NMZ1; pGluN1
Gene Aliases: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; MRD8; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174