MA1-10881 detects Glutamate NMDA Receptor NR3A/B Subunit from human, mouse, and rat samples. This antibody does not cross-react with subunits NR1 or NR2A-D.
MA1-10881 has been successfully used in Western blot and immunoprecipitation applications.
The MA1-10881 immunogen is Fusion protein of NR3A amino acids 780-914 from the extracellular III-IV loop.
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
Protein Aliases: GluN3A; GluN3B; glutamate [NMDA] receptor subunit 3A; glutamate [NMDA] receptor subunit 3B; glutamate receptor; Glutamate receptor chi-1; Glutamate receptor ionotropic, NMDA 3A; Glutamate receptor ionotropic, NMDA 3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B; glutamate receptor, ionotropic, NMDA3B; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3A; N-methyl-D-aspartate receptor subtype 3B; N-methyl-D-aspartate receptor subunit NR3B; NMDA receptor 4; NMDA receptor subunit 3B; NMDA type glutamate receptor subunit NR3B; NMDAR-L; NMDAR-L1; NMDAR3A; NMDAR3B; Nr4
Gene Aliases: 6430537F04; A830097C19Rik; chi-1; GluN3A; GluN3B; GRIN3A; GRIN3B; KIAA1973; mKIAA1973; NMDAR-L; NMDAR3B; NR3; NR3A; NR3B