Positive control: Normal Human skin fibroblasts (strain HDFn); Human cerebellum tissue; mitochondria from Human liver, Bovine heart, Rat liver and Mouse liver; HepG2 and HL-60 cells.
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.
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Protein Aliases: mitochondrial; NAD(P) transhydrogenase; NAD(P) transhydrogenase, mitochondrial; Nicotinamide nucleotide transhydrogenase; Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase); Pyridine nucleotide transhydrogenase
Gene Aliases: 4930423F13Rik; AI323702; BB168308; BOS_19786; GCCD4; NNT