This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Four transcript variants encoding three distinct isoforms have been identified for this gene.
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Protein Aliases: CHN; chondrosarcoma; chondrosarcoma, extraskeletal myxoid, fused to EWS; CSMF; extraskeletal myxoid; fused to EWS; MINOR; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; TEC; translocated in extraskeletal chondrosarcoma
Gene Aliases: CHN; CSMF; MINOR; NOR1; NR4A3; TEC
UniProt ID: (Human) Q92570
Entrez Gene ID: (Human) 8013