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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:5,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Expression System |
HEK293 cells |
Class |
Recombinant Monoclonal |
Type |
Antibody |
Clone |
4F6 |
Immunogen |
A synthesized peptide derived from human Notch1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol, 150mM NaCl |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C or -80°C if preferred |
RRID |
AB_2898283 |
This antibody has been tested in direct-ELISA
The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Neurogenic locus notch homolog protein 1; NEXT; NICD; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch homolog 1, translocation-associated; RP23-306D20.12; RP23-306D20.12-001; Translocation-associated notch protein TAN-1
Gene Aliases: AOS5; AOVD1; hN1; NOTCH1; TAN1
UniProt ID: (Human) P46531
Entrez Gene ID: (Human) 4851
Molecular Function:
cell adhesion molecule
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