This Antibody was verified by IP Mass Spectrometry to ensure that the antibody binds to the antigen stated. View Details
This antibody is specific for the Notch1 (neurogenic locus notch homolog protein1, Motch A, mT14, p300) protein. This antibody gives a band of ~65 kDa on Western blot analysis using Notch1-IC OP transfected cells. Western blot analysis using Jurkat cells expresses the target band at ~110-120 kDa, with an additional band occasionally observed at ~220kDa. This antibody does not cross-react with Notch 2,3, and 4 as assessed by Western blot analysis.
Notch1 is a single transmembrane receptor expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 9930111A19Rik; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch A; mT14; N1; Neurogenic locus notch homolog protein 1; Notch 1; Notch gene homolog 1; Notch homolog 1, translocation-associated; p300; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
Gene Aliases: 9930111A19Rik; AOS5; AOVD1; BOS_12152; hN1; lin-12; Mis6; Motch; N1; NOTCH; NOTCH1; TAN1