Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
68212-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2D5E1
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PAHALQCRDG YEPCVNEGMC VTYHNGTGYC KCPEGFLGEY CQHRDPCEKN RCQNGGTCVA QAMLGKATCR CASGFTGEDC QYSTSHPCFV SRPCLNGGTC HMLSRDTYEC TCQVGFTGKE CQWTDACLSH PCANGSTCTT VANQFSCKCL TGFTGQKCET DVNECDIPGH CQHGGICLNL PGSYQCQCLQ GFTGQYCDSL YVPCAPSPCV NGGTCRQTGD FTFECNCLPE TVRRGTELWE RDREVWNGKE HDEN
Target Information
NOTCH2 and NOTCH2NL are members of the Notch receptor family, with NOTCH2 being a transmembrane receptor located on the cell surface. It plays a critical role in cell-to-cell communication during development and tissue homeostasis, affecting cell fate determination, differentiation, proliferation, and apoptosis. NOTCH2 is composed of an extracellular domain with epidermal growth factor-like repeats, a transmembrane domain, and an intracellular domain. On the other hand, NOTCH2NL proteins are also transmembrane proteins that modulate NOTCH2 signaling. They can act as competitive inhibitors or enhancers of NOTCH2 signaling, depending on the specific paralog and cellular context. They are involved in neuronal development and have been linked to human brain evolution, particularly in neocortex expansion. Both NOTCH2 and NOTCH2NL are important players in cellular processes and have structural similarities, but NOTCH2NL proteins have distinct arrangements of domains compared to NOTCH2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2; Notch homolog 2 N-terminal like protein; Notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A
Gene Aliases: AGS2; HJCYS; hN2; N2N; NOTCH2; NOTCH2NL; NOTCH2NLA
UniProt ID: (Human) Q04721, (Human) Q7Z3S9
Entrez Gene ID: (Human) 4853, (Human) 388677
Notch signaling pathway
multicellular organism development
cell differentiation
cell fate determination
marginal zone B cell differentiation
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
apoptotic process
cell cycle arrest
nervous system development
negative regulation of cell proliferation
organ morphogenesis
cell growth
stem cell population maintenance
hemopoiesis
intracellular receptor signaling pathway
tissue regeneration
negative regulation of apoptotic process
positive regulation of Ras protein signal transduction
bone remodeling
regulation of developmental process
atrial septum morphogenesis
Notch signaling involved in heart development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support