Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MKPTGTDPRI LSIAAEVAKS PEQNVPVILL KLKEIINITP LGSSELKKIK QDIYCYDLIQ YCLLVLSQDY SRIQGGWTTI SQLTQILSHC CVGLEPGEDA EEFYNELLPS AAENFLVLGR QLQTCFINAA KAEEKDELLH FFQIVTDSLF WLLGGHVELI QNVLQSDHFL HLLQADNVQI GSAVMMMLQN ILQINRSKRS KMLLEINRQK EEEDLKLQLQ LQRQRAMRLS RELQLSMLEI VHPGQVEKHY REMEEKSALI IQKHWRGYRE RKNFHQQRQS LIEYKAAVTL QRAALKFLAK YRKKKKLFAP WRGLQELTDA RRVELKKRVD DYVRRHLGSP MSDVVSRELH
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: IQ calmodulin-binding motif-containing protein 1; nephrocystin 5; Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein; PIQ
Gene Aliases: IQCB1; KIAA0036; NPHP5; OK/SW-cl.85; PIQ; SLSN5
UniProt ID: (Human) Q15051
Entrez Gene ID: (Human) 9657
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