Immunogen sequence: LVAHRHGMTS GDYAFFNIEL FNSSSYGDGS WKRGDKHDFE AKQAYSSLQT VTLLRTVKPE FEKFSMEVKS SVEKQGLNME DYVNMFVEGF HDAILLYVLA LHEVLRAGYS KKDGGKIIQQ TWNRTFEGIA GQVSIDANGD RYGDFSVIAM TDVEAGTQEV IGDYFGKEGR FEMRPNVKYP WGPLKLRIDE NRIVEHTNSS PCKSSGGLEE SAVTGIVVGA LLGAGLLMAF YFFRKKYRIT IERRTQQEES NLGKHRELRE DSIRSHFSVA; Positive Samples: A-549, Mouse lung; Cellular Location: Membrane, Single-pass type I membrane protein
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
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Protein Aliases: ANP-C; ANPR-C; ANPRC; atrial natriuretic peptide C-type receptor; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide clearence receptor 3; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide receptor type C; atrionatriuretic peptide receptor C; EF-2; guanylate cyclase C; longjohn; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); Nppc receptor; NPR-C; strigosus
Gene Aliases: ANP-C; ANP-CR; ANPR-C; ANPRC; C5orf23; EF-2; GUCY2B; lgj; NPR-C; NPR3; NPRC; stri