Immunogen sequence: MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI ETVVGVLGNL CLMCVTVRQK EKANVTNLLI; Positive Samples: MCF-7, SH-SY5Y, SW480, HT-29; Cellular Location: Cell membrane, Multi-pass membrane protein
Aurora A is a 46 kDa protein that plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Multiple transcript variants encoding the same protein have been found for this gene. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal.
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Protein Aliases: Neuropeptide Y receptor type 4; NPY4-R; Pancreatic polypeptide receptor 1; PP1
Gene Aliases: NPY4-R; NPY4R; PP1; PPYR1; Y4
UniProt ID: (Human) P50391
Entrez Gene ID: (Human) 5540