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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1-5 µg/mL | - |
Immunocytochemistry (ICC/IF) |
10 µg/mL | - |
ELISA (ELISA) |
0.03 ng/mL | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Rat |
Host/Isotype |
Mouse / IgG2a, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
1E1 |
Immunogen |
NR1H2 (AAH07790.1, 1 a.a. approximately 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Sequence of this protein is as follows: MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQQESQS QSQSPVGPQG SSSSASGPGA SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK RSFSDQPKVT PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ IALLKASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI NPIFEFSRAM RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV EALLSYTRIK RPQDQLRFPR MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP PLLSEIWDVH E
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; UR
Gene Aliases: LXR-b; LXRB; NER; NER-I; NR1H2; OR-1; RIP15; UNR
UniProt ID: (Human) P55055, (Rat) Q62755
Entrez Gene ID: (Human) 7376, (Rat) 58851
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