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NR1H2 Monoclonal Antibody (1E12B10)

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NR1H2 Antibody (60345-1-IG) in WB

Human liver tissue were subjected to SDS PAGE followed by western blot with 60345-1-IG ( NR1H2 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

60345-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

ChIP assay (ChIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Pig

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1E12B10

Immunogen

NR1H2 Fusion Protein Ag5635 (1-461 aa encoded by BC047750)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSSPTTSSL DTPLPGNGPP QPGAPSSSPT VKEEGPEPWP GGPDPDVPGT DEASSACSTD WVIPDPEEEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVRGG ARRYACRGGG TCQMDAFMRR KCQQCRLRKC KEAGMREQCV LSEEQIRKKK IRKQQQQESQ SQSQSPVGPQ GSSSSASGPG ASPGGSEAGS QGSGEGEGVQ LTAAQELMIQ QLVAAQLQCN KRSFSDQPKV TPWPLGADPQ SRDARQQRFA HFTELAIISV QEIVDFAKQV PGFLQLGRED QIALLKASTI EIMLLETARR YNHETECITF LKDFTYSKDD FHRAGLQVEF INPIFEFSRA MRRLGLDDAE YALLIAINIF SADRPNVQEP GRVEALQQPY VEALLSYTRI KRPQDQLRFP RMLMKLVSLR TLSSVHSEQV FALRLQDKKL PPLLSEIWDV HE (1-461 aa encoded by BC047750)

Target Information

The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.

Acta pharmacologica Sinica

He XY,Zhu MM,Zheng J,Wang CY,Zhao XK,Zhang BT,Zhou DC,Zhang S,Yang XX,Duan YJ,Han JH,Chen YL

Wed Mar 01 00:00:00 UTC 2023

Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.

Acta pharmacologica Sinica

He XY,Zhu MM,Zheng J,Wang CY,Zhao XK,Zhang BT,Zhou DC,Zhang S,Yang XX,Duan YJ,Han JH,Chen YL

Wed Mar 01 00:00:00 UTC 2023

Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.

Acta pharmacologica Sinica

He XY,Zhu MM,Zheng J,Wang CY,Zhao XK,Zhang BT,Zhou DC,Zhang S,Yang XX,Duan YJ,Han JH,Chen YL

Wed Mar 01 00:00:00 UTC 2023

Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.

Acta pharmacologica Sinica

He XY,Zhu MM,Zheng J,Wang CY,Zhao XK,Zhang BT,Zhou DC,Zhang S,Yang XX,Duan YJ,Han JH,Chen YL

Wed Mar 01 00:00:00 UTC 2023

Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.

Food & function

Wang D,Yin Z,Ma L,Han L,Chen Y,Pan W,Gong K,Gao Y,Yang X,Chen Y,Han J,Duan Y

Mon Jun 07 00:00:00 UTC 2021

Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.

Food & function

Wang D,Yin Z,Ma L,Han L,Chen Y,Pan W,Gong K,Gao Y,Yang X,Chen Y,Han J,Duan Y

Mon Jun 07 00:00:00 UTC 2021

Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.

Journal of agricultural and food chemistry

Luo N,Yang C,Zhu Y,Chen Q,Zhang B

Wed Jan 20 00:00:00 UTC 2021

TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.

The Journal of biological chemistry

Zhao D,Li J,Xue C,Feng K,Liu L,Zeng P,Wang X,Chen Y,Li L,Zhang Z,Duan Y,Han J,Yang X

Fri Nov 27 00:00:00 UTC 2020

EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.

Frontiers in oncology

Chen T,Xu J,Fu W

Tue Nov 24 00:00:00 UTC 2020

Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.

Biochemical and biophysical research communications

Wang X,Zhao H,Yan W,Liu Y,Yin T,Wang S,Fan M,Li C,Zhang L,Tao L

Tue Sep 03 00:00:00 UTC 2019

Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.

British journal of pharmacology

Ma C,Zhang W,Yang X,Liu Y,Liu L,Feng K,Zhang X,Yang S,Sun L,Yu M,Yang J,Li X,Hu W,Miao RQ,Zhu Y,Li L,Han J,Chen Y,Duan Y

Tue May 01 00:00:00 UTC 2018

Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.

British journal of pharmacology

Ma C,Zhang W,Yang X,Liu Y,Liu L,Feng K,Zhang X,Yang S,Sun L,Yu M,Yang J,Li X,Hu W,Miao RQ,Zhu Y,Li L,Han J,Chen Y,Duan Y

Tue May 01 00:00:00 UTC 2018

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.

Journal of lipid research

Liu Y,Wei Z,Zhang Y,Ma X,Chen Y,Yu M,Ma C,Li X,Cao Y,Liu J,Han J,Yang X,Duan Y

Sat Dec 01 00:00:00 UTC 2018

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.

Journal of lipid research

Liu Y,Wei Z,Zhang Y,Ma X,Chen Y,Yu M,Ma C,Li X,Cao Y,Liu J,Han J,Yang X,Duan Y

Sat Dec 01 00:00:00 UTC 2018

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.

Journal of lipid research

Liu Y,Wei Z,Ma X,Yang X,Chen Y,Sun L,Ma C,Miao QR,Hajjar DP,Han J,Duan Y

Thu Mar 01 00:00:00 UTC 2018

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.

Journal of lipid research

Liu Y,Wei Z,Ma X,Yang X,Chen Y,Sun L,Ma C,Miao QR,Hajjar DP,Han J,Duan Y

Thu Mar 01 00:00:00 UTC 2018

Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells.

Biochemical and biophysical research communications

Guo F,Hong W,Yang M,Xu D,Bai Q,Li X,Chen Z

Fri Oct 12 00:00:00 UTC 2018

Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells.

Biochemical and biophysical research communications

Guo F,Hong W,Yang M,Xu D,Bai Q,Li X,Chen Z

Fri Oct 12 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor

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Gene Aliases: LXR-b; LXRB; NER; NER-I; NR1H2; RIP15; UNR

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UniProt ID: (Human) P55055

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Entrez Gene ID: (Human) 7376, (Pig) 100525290

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding apolipoprotein A-I receptor binding retinoid X receptor binding ATPase binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NR1H2 Monoclonal Antibody (1E12B10)

NR1H2 Antibody (60345-1-IG) in WB

Product Details

60345-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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