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Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 4 publications 4 publications |
Product Specifications | |
---|---|
Species Reactivity |
Human, Pig |
Published species |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
1E12B10 |
Immunogen |
NR1H2 Fusion Protein Ag5635 (1-461 aa encoded by BC047750) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MSSPTTSSL DTPLPGNGPP QPGAPSSSPT VKEEGPEPWP GGPDPDVPGT DEASSACSTD WVIPDPEEEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVRGG ARRYACRGGG TCQMDAFMRR KCQQCRLRKC KEAGMREQCV LSEEQIRKKK IRKQQQQESQ SQSQSPVGPQ GSSSSASGPG ASPGGSEAGS QGSGEGEGVQ LTAAQELMIQ QLVAAQLQCN KRSFSDQPKV TPWPLGADPQ SRDARQQRFA HFTELAIISV QEIVDFAKQV PGFLQLGRED QIALLKASTI EIMLLETARR YNHETECITF LKDFTYSKDD FHRAGLQVEF INPIFEFSRA MRRLGLDDAE YALLIAINIF SADRPNVQEP GRVEALQQPY VEALLSYTRI KRPQDQLRFP RMLMKLVSLR TLSSVHSEQV FALRLQDKKL PPLLSEIWDV HE (1-461 aa encoded by BC047750)
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor
Gene Aliases: LXR-b; LXRB; NER; NER-I; NR1H2; RIP15; UNR
UniProt ID: (Human) P55055
Entrez Gene ID: (Human) 7376, (Pig) 100525290
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