Abnova

NR4A3 Monoclonal Antibody (1E9)

View all (29) NOR-1 antibodies

Questions & Answers

Questions & Answers

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NR4A3 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence of monoclonal antibody to NR4A3 on HeLa cell. Antibody concentration is 10 µg/mL.

NR4A3 Antibody in Western Blot (WB) — NR4A3 monoclonal antibody (M02), clone 1E9 Western Blot analysis of NR4A3 expression in HeLa S3 NE (Cat # L013V3).

NR4A3 Antibody in ELISA (ELISA) — Detection limit for recombinant GST tagged NR4A3 is approximately 0.3 ng/mL as a capture antibody.

Product Details

H00008013-M02

Applications	Tested Dilution	Publications
Western Blot (WB)	1-5 µg/mL	-
Immunocytochemistry (ICC/IF)	10 µg/mL	-
ELISA (ELISA)	0.3 ng/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG2a, kappa
Class	Monoclonal
Type	Antibody
Clone	1E9
Immunogen	NR4A3 (NP_008912, 414 a.a. approximately 521 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	See Label
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4
Contains	no preservative
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Sequence of this protein is as follows: LDYSRYCPTD QAAAGTDAEH VQQFYNLLTA SIDVSRSWAE KIPGFTDLPK EDQTLLIESA FLELFVLRLS IRSNTAEDKF VFCNGLVLHR LQCLRGFGEW LDSIKDFS

Target Information

NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; TEC receptor; translocated in extraskeletal chondrosarcoma

Gene Aliases: CHN; CSMF; MINOR; NOR1; NR4A3; TEC

UniProt ID: (Human) Q92570

Entrez Gene ID: (Human) 8013

Molecular Function: C4 zinc finger nuclear receptor

negative regulation of transcription from RNA polymerase II promoter mesoderm formation transcription initiation from RNA polymerase II promoter gastrulation axon guidance biological_process pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transport hippocampus development intracellular receptor signaling pathway adult behavior organ regeneration positive regulation of mast cell cytokine production common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway response to hydrogen peroxide mast cell degranulation steroid hormone mediated signaling pathway negative regulation of neuron apoptotic process cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation negative regulation of hydrogen peroxide-induced neuron death positive regulation of leukocyte apoptotic process positive regulation of feeding behavior regulation of energy homeostasis

Process(es)

RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding DNA binding steroid hormone receptor activity thyroid hormone receptor activity protein binding zinc ion binding protein kinase binding histone acetyltransferase binding glucocorticoid receptor binding protein homodimerization activity