MA5-12896 targets Heregulin in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-12896 immunogen is recombinant extracellular domain of rat NDF protein.
Heregulin (HRG) or neu differentiation factor (NDF) binds to c-erbB-3 and c-erbB-4 receptors on mammary and neuronal cells with low and high affinities, respectively. HRG/NDF exists in several isoforms, which are classified in two groups, alpha and beta that differ in their EGF-like domain and in receptor binding affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acetylcholine receptor-inducing activity; alpha (45kD; ARIA; Breast cancer cell differentiation factor p45; ERBB2 p185-activator); Glial growth factor; glial growth factor 2; Heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); HRG; membrane-bound isoform; Neu differentiation factor; neuregulin 1 type III beta 3; Neuregulin-1; pro-neuregulin-1; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; Sensory and motor neuron-derived factor; type I neuregulin 1; type III neuregulin 1
Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF