MA5-12896 targets Heregulin in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-12896 immunogen is recombinant extracellular domain of rat NDF protein.
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; glial growth factor 2; Heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); HRG; Neu differentiation factor; neuregulin 1 type III beta 3; Neuregulin-1; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; Sensory and motor neuron-derived factor; type I neuregulin 1; type III neuregulin 1
Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
Molecular Function: growth factor