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Proteintech
NRG1, isoform SMDF Recombinant Rabbit Monoclonal Antibody (240184G2)
Product Details
83323-6-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
240184G2
Immunogen
NRG1, isoform SMDF fusion protein Ag0803
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG LVGLAVPCCA CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD PIISLDATAA SALWVSSEAY TSPVSRAQSE SEVQVTVQGD KAVVSFEPSA APTPKNRIFA FSFLPSTAPS FPSPTRNPEV RTPKSATQPQ TTETNLQTAP KLSTS
Target Information
Neuregulin-1 (NRG1) is a gene encoding multiple isoforms involved in various physiological functions, particularly within the nervous system. The SMDF (sensory and motor neuron-derived factor) is one such isoform of NRG1. Located on chromosome 8p12, NRG1 comprises several exons, where alternative splicing gives rise to the diverse isoforms. The SMDF isoform of NRG1 plays a critical role in neural development and the maintenance of neuronal functions, including neurotransmission and synaptic plasticity. This isoform signals through interactions with ErbB family receptors, predominantly ErbB3 and ErbB4, facilitating cellular communication necessary for proper neural function. NRG1, including its SMDF variant, has been implicated in neuropsychiatric conditions such as schizophrenia and bipolar disorder, underscoring its significance in both development and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1
Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297
Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323
transcription cofactor activity
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
cytokine activity
ErbB-2 class receptor binding
integrin binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
receptor binding
protein tyrosine kinase activator activity
growth factor
MAPK cascade
activation of MAPK activity
cell morphogenesis
startle response
cardiac conduction system development
ventricular trabecula myocardium morphogenesis
cell communication
activation of transmembrane receptor protein tyrosine kinase activity
nervous system development
synapse assembly
peripheral nervous system development
locomotory behavior
regulation of blood pressure
positive regulation of cell proliferation
embryo development
neural crest cell development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
peptidyl-tyrosine phosphorylation
glial cell fate commitment
chemorepulsion involved in interneuron migration from the subpallium to the cortex
mammary gland development
positive regulation of myelination
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
wound healing
negative regulation of protein catabolic process
myelination
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
positive regulation of GTPase activity
neurotransmitter receptor metabolic process
positive regulation of axon extension
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
neuron fate commitment
oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of secretion
positive regulation of striated muscle cell differentiation
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
positive regulation of dendritic spine development
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of protein targeting to mitochondrion
positive regulation of protein localization to cell surface
regulation of cell motility
positive regulation of cardiac muscle cell differentiation
negative regulation of neuron migration
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
muscle organ development
cell proliferation
glial cell differentiation
negative regulation of cardiac muscle cell apoptotic process
cell migration
cell differentiation
positive regulation of cell growth
cellular protein complex disassembly
regulation of cell differentiation
positive regulation of cell adhesion
positive regulation of protein kinase activity
animal organ development
ventricular cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
positive regulation of protein tyrosine kinase activity
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
axon ensheathment
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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