Sequence of this protein is as follows: RNDKCGDTIK IESPGYLTSP GYPHSYHPSE KCEWLIQAPD PYQRIMINFN PHFDLEDRDC KYDYVEVFDG ENENGHFRGK FCGKIAPPPV VSSGPFLFIK FVSDYETHGA GFSIRYEIFK RGPECSQNYT TPSGVIKSPG FPEKYPNSLE CTYIVFALKM SEIILEFESF DLEPDSNPPG GMFCRYDRLE IRDGFPDVGP HIGRYCGQKT PGRIRSSSGI LSMVFYTDSA IAKEGFSANY SVLQSSVSED FKCMEALGME SGEIHSDQIT ASSQYSTNWS AERSRLNYPE NGWTPGEDSY REWIQVDLGL LRFVTAVGTQ GAISKETKKK YYVKTYKIDV SSNGEDWITI KEGNKPVLFQ GNTNPTDVVV AVFPKPLITR FVRIKPATWE TGISMRFEVY GCKITDYPCS GMLGMVSGLI SDSQITSSNQ GDRNWMPENI RLVTSRSGWA LPPAPHSYIN EWLQIDLGEE KIVRGIIIQG GKHRENKVFM RKFKIGYSNN GSDWKMIMDD SKRKAKSFEG NNNYDTPELR TFPALSTRFI RIYPERATHG GLGLRMELLG CEVEAPTAGP TTPNGNLVDE CDDDQANCHS GTGDDFQLTG GTTVLATEKP TVIDSTIQSG IK
Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.
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Protein Aliases: CD304; Neuropilin; Neuropilin-1; Neuropilin1; NRP 1; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; Vascular endothelial cell growth factor 165 receptor
Gene Aliases: BDCA4; CD304; NP1; NRP; NRP1; VEGF165R
UniProt ID: (Human) O14786
Entrez Gene ID: (Human) 8829
Molecular Function: oxidoreductase