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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant full length human NSD1 / KMT3B|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7.4, with 0.15M NaCl, 50% glycerol|
|Contains||0.2% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous levels of NSD1 / KMT3B at a molecular weight of 300 kDa and does not cross-react with related proteins.
Purity is >95% by SDS-PAGE.
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
androgen receptor coactivator 267 kDa protein; androgen receptor-associated coregulator 267; androgen receptor-associated protein of 267 kDa; ARA267; H3 lysine-36 and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase; Histone-lysine N-methyltransferase; KMT3B; lysine N-methyltransferase 3B; NR-binding SET domain-containing protein; NSD1; nuclear receptor-binding SET domain-containing protein 1
ARA267; KMT3B; NSD1; SOTOS; SOTOS1; STO