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NeoBiotechnologies
NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3/8796)
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Product Details
4916-MSM4-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
NTRK3/8796
Immunogen
Recombinant fragment (around aa 100-300) of human NTRK3 protein (exact sequence is proprietary).
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product cellular localization: Cell surface.
Positive control: Human brain tissue.
Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.
Target Information
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Aliases: gp145(trkC); GP145-TrkC; NTRK3; TRKC
UniProt ID: (Human) Q16288, (Rat) Q03351
Entrez Gene ID: (Human) 4916, (Rat) 29613
activation of MAPK activity
neuron migration
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
circadian rhythm
positive regulation of cell proliferation
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
modulation by virus of host transcription
positive regulation of cell migration
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
response to ethanol
protein autophosphorylation
ephrin receptor signaling pathway
neuron fate specification
response to axon injury
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
positive regulation of positive chemotaxis
response to corticosterone
positive regulation of synapse assembly
negative regulation of cell death
lens fiber cell differentiation
cellular response to retinoic acid
cochlea development
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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