Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 3
Sequence of this protein is as follows: KGDIAECSPA VCMDPGLSNC TIHIVTVTIN GDDAENARPK PKPGDGEFVE VISLPKNDLL QRLDALVAEE HLTVDARVYS YALALKHANA KPFEVPFLKF
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; Nudix motif 5; YSA1H
Gene Aliases: HSPC115; NUDIX5; NUDT5; YSA1; YSA1H; YSAH1
UniProt ID: (Human) Q9UKK9
Entrez Gene ID: (Human) 11164
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