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NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), also known as Antisense basic fibroblast growth factor or GFG-1, is a member of the Nudix hydrolase family of pyrophosphatases. Nudix hydrolases contain a characteristic Nudix domain and are responsible for catalyzing the hydrolysis of nucleoside diphosphate derivatives. The gene encoding NUDT6 is a FGF-2 gene antisense transcript, and NUDT6 is believed to regulate FGF-2 expression. FGF-2 is a mutifunctional heparin-binding growth factor important to angiogenesis, neuroectoderm development and wound healing. NUDT6 is expressed as two isoforms produced by alternative splicing.
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Protein Aliases: Antisense basic fibroblast growth factor; Nucleoside diphosphate-linked moiety X motif 6; nudix (nucleoside diphosphate linked moiety X)-type motif 6; Nudix motif 6; Protein GFG
Gene Aliases: ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1; NUDT6
UniProt ID: (Human) P53370
Entrez Gene ID: (Human) 11162
Molecular Function: nucleotide phosphatase