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This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: cancer/testis antigen 106; cell division cycle associated 1; Cell division cycle-associated protein 1; hNuf2; hNuf2R; hsNuf2; Kinetochore protein Nuf2; NUF2, NDC80 kinetochore complex component, homolog
Gene Aliases: CDCA1; CT106; NUF2; NUF2R
UniProt ID: (Human) Q9BZD4
Entrez Gene ID: (Human) 83540
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