MA5-12645 targets NY-BR-1 in IHC (P, F) applications and shows reactivity with Human samples.
The MA5-12645 immunogen is a 77 aa peptide from human NYBR-1 protein.
NY-BR-1 is a novel differentiation marker predominantly expressed in normal breast and breast cancer. It has been shown by Immunohistochemistry (IHC) that NY-BR-1 was present solely in ductal epithelium of normal breast tissue. Invasive carcinoma of the breast and carcinoma in situ were positive for NY-BR-1, whereas most other tumors and normal tissues are negative, with the exceptions of one-third of sweat gland carcinomas and around two percent of prostate carcinoma. NY-BR-1 is reported to express more frequently in estrogen-positive and lymph node-negative primary carcinomas, and more commonly in grade 1 than in grade 2 or grade 3. In a study by Varga et al (2006) forty-nine percent of lymph node metastasis were shown to be positive.
Protein Aliases: Ankyrin repeat domain-containing protein 30A; breast cancer antigen NY-BR-1; Serologically defined breast cancer antigen NY-BR-1
Gene Aliases: ANKRD30A; NY-BR-1
UniProt ID: (Human) Q9BXX3
Entrez Gene ID: (Human) 91074