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|Tested species reactivity||Mouse, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 251-266 of human Nur77 (Nak-1).|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||1:10-1:500|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: MOLT-4 or NIH-3T3.
Nur77 (Nak-1) is a member of the steroid/thyroid hormone receptor superfamily. The gene for Nur77 is induced rapidly by androgens/growth factors and may have functions related to cell proliferation, differentiation and apoptosis (1). Liu et al (2) have demonstrated that mouse nur77 is necessary for induced apoptosis in T-cell hybridomas and can also be induced during early mitogenesis. Nur77 (Nak-1) is a phosphoprotein and its size ranges from 67 kD to 88 kD, depending on post-translational modifications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; N10; NAK-1; nerve growth factor IB nuclear receptor variant 1; NGFIB; NP10; nuclear hormone receptor NUR/77; nuclear protein N10; nuclear receptor subfamily 4 group A member 1; orphan nuclear receptor HMR; orphan nuclear receptor TR3; ST-59; steroid receptor TR3; testicular receptor 3; TR3; TR3 orphan receptor
Gfrp; GFRP1; Hbr-1; Hbr1; HMR; N10; NAK-1; NGFI-B; NGFIB; NP10; NUR77; TIS1; TR3
Nucleoside, nucleotide and nucleic acid metabolism mRNA transcription mRNA transcription regulation Signal transduction Immunity and defense Stress response Developmental processes Ectoderm development Neurogenesis