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Antibodies Inc
Navbeta1 Na+ Channel Monoclonal Antibody (N405/74), FL490
Product Details
75-425-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N405/74
Immunogen
Fusion protein amino acids 14-160 (extracellular N-terminus) of rat Navbeta1 (accession number Q00954) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel voltage-gated type 1 beta polypeptide; sodium channel voltage-gated type I beta polypeptide; sodium channel, voltage-gated, type 1, beta polypeptide; sodium channel, voltage-gated, type I, beta polypeptide
Gene Aliases: Scn1b
UniProt ID: (Mouse) P97952, (Rat) Q00954
Entrez Gene ID: (Mouse) 20266, (Rat) 29686
voltage-gated ion channel activity
voltage-gated sodium channel activity
sodium channel activity
protein binding
sodium channel regulator activity
sodium channel inhibitor activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
ion channel
transporter
voltage-gated ion channel
regulation of sodium ion transport
transport
ion transport
sodium ion transport
axon guidance
positive regulation of sodium ion transport
positive regulation of neuron projection development
neuronal action potential propagation
corticospinal neuron axon guidance
regulation of ion transmembrane transport
sodium ion transmembrane transport
locomotion
response to pyrethroid
membrane depolarization
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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