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Abnova
Nefl Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB01636
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to mouse 68kDa Neurofilament.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 150mM NaCl, 40% glycerol, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit and runs on SDS-PAGE gels at approximately 70 kDa. Neurofilament are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the heavy or high molecular weight microfilament subunit and runs on SDS-PAGE gels in the range 180-220 kDa, with some variation in different species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 68 kDa neurofilament protein; FLJ53642; N-FL; NEF3; NEFL; neurofilament; neurofilament 3; neurofilament triplet L protein; neurofilament-l; neurofilament-light; NF-M; NFM; NLC; OTTHUMP00000196614
Gene Aliases: CMT2E; NF-L; NF68; Nfl
UniProt ID: (Mouse) P08551
Entrez Gene ID: (Mouse) 18039
structural constituent of cytoskeleton
protein binding
tubulin binding
protein domain specific binding
protein binding, bridging
identical protein binding
phospholipase binding
macromolecular complex binding
structural constituent of postsynaptic intermediate filament cytoskeleton
molecular condensate scaffold activity
microtubule cytoskeleton organization
anterograde axonal transport
retrograde axonal transport
response to toxic substance
peripheral nervous system axon regeneration
axonal transport of mitochondrion
spinal cord development
hippocampus development
cerebral cortex development
regulation of axon diameter
neurofilament bundle assembly
locomotion
response to peptide hormone
negative regulation of neuron apoptotic process
intermediate filament polymerization or depolymerization
intermediate filament polymerization
intermediate filament organization
intermediate filament bundle assembly
neuron projection morphogenesis
positive regulation of axonogenesis
neuromuscular process controlling balance
protein polymerization
response to corticosterone
neurofilament cytoskeleton organization
regulation of synapse maturation
postsynaptic modulation of chemical synaptic transmission
postsynaptic intermediate filament cytoskeleton organization
response to sodium arsenite
response to acrylamide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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