NENF is a secreted protein that is expressed in neurons but not glial cells of the brain. This protein has neurotrophic activity in primary cultured mouse neurons but not mitogenic activity in primary cultured mouse astrocytes. NENF activated mitogen-activated protein (MAP) and phosphotidylinositol-3 kinase pathways and could be inhibited by pertussis toxin but not receptor tyrosine kinases, suggesting that NENF acts through a Gi/Go-protein-coupled receptor.
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Protein Aliases: cell growth-inhibiting protein 47; Cell immortalization-related protein 2; Neudesin; Neuron-derived neurotrophic factor; Protein GIG47; SCIRP10-related protein; Secreted protein of unknown function; Spinal cord injury related protein 10; SPUF protein
Gene Aliases: 1110060M21Rik; CIR2; NENF; SCIRP10; SPUF
Molecular Function: transmembrane signal receptor