Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells. In the course of mouse neurogenesis, Ngn2 and Ngn1 are expressed in distinct progenitor populations residing in the central and peripheral nervous systems. Mutation analyses demonstrate that Ngn1 is required for the determination of neuronal precursors for proximal cranial sensory ganglia and that Ngn2 is necessary for the determination of precursors for epibranchial placode-derived sensory neurons.
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Protein Aliases: ATOH4; atonal homolog 4; bHLHa8; Class A basic helix-loop-helix protein 8; Helix-loop-helix protein mATH-4A; mATH4A; NEUROG2; Neurogenin-2; NGN-2; NGN2; Protein atonal homolog 4
Gene Aliases: Ath4a; ATOH4; BHLHA8; Math4A; NEUROG2; ngn-2; NGN2