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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse, Rat |
Host/Isotype |
Rabbit / Ig |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide from aa region 150-200 of rat Neurokinin 1 Receptor conjugated to blue carrier protein was used as the antigen |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Storage buffer |
whole serum |
Contains |
no preservative |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
Reconstitute in 100 µL of MQ water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: Neurokinin 1 Receptor.
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1
Gene Aliases: Nk1r; Spr; Tac1r; Tacr1
UniProt ID: (Mouse) P30548, (Rat) P14600
Entrez Gene ID: (Mouse) 21336, (Rat) 24807
Molecular Function:
G-protein coupled receptor
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