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Neurokinin 1 Receptor Antibody (OSN00078W-100UL) in IHC (P)
IHC-P on paraffin sections of mouse brain. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions... View More
Product Details
OSN00078W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 150-200 of rat Neurokinin 1 Receptor conjugated to blue carrier protein was used as the antigen
Conjugate
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Product Specific Information
Reconstitute in 100 µL of MQ water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: Neurokinin 1 Receptor.
Target Information
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1
Gene Aliases: Nk1r; Spr; Tac1r; Tacr1
UniProt ID: (Mouse) P30548, (Rat) P14600
Entrez Gene ID: (Mouse) 21336, (Rat) 24807
Molecular Function:
G-protein coupled receptor
aggressive behavior
positive regulation of leukocyte migration
angiotensin-mediated drinking behavior
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
learning or memory
long-term memory
regulation of blood pressure
associative learning
response to heat
response to hormone
response to ozone
positive regulation of epithelial cell migration
response to auditory stimulus
response to organic cyclic compound
regulation of smooth muscle cell migration
sensory perception of pain
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to nicotine
operant conditioning
positive regulation of renal sodium excretion
sperm ejaculation
eating behavior
positive regulation of vascular permeability
response to ethanol
positive regulation of action potential
positive regulation of blood pressure
positive regulation of ossification
positive regulation of vasoconstriction
positive regulation of saliva secretion
positive regulation of hormone secretion
response to pain
behavioral response to pain
regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of epithelial cell proliferation
positive regulation of stress fiber assembly
smooth muscle contraction involved in micturition
positive regulation of uterine smooth muscle contraction
acute inflammatory response
response to estradiol
response to progesterone
response to morphine
response to electrical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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