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Neurokinin 1 Receptor staining in paraffin-embedded human skin tissue. Tissue sections were stained with Neurokinin 1 Receptor Polyclonal Antibody (Product # PA3-301) at a dilution of 1:750 followed by anti-rabbit IgG-HRP secondary and a fluorescently-conjugated tyramide reagent (red). Data courtesy of the Innovators Program.
|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues S(387) S R S D S K T M T E S F S F S S N V L S(407) of human NK1 receptor protein.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:1,000|
|Western Blot (WB)||1:5,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA3-301 detects neurokinin-1 receptor in human samples.
PA3-301 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures.
The PA3-301 immunogen is a synthetic peptide corresponding to residues S(387) S R S D S K T M T E S F S F S S N V L S(407) of human NK1 receptor protein.
NK1 receptors are frequently expressed in glioblastomas and breast and pancreatic carcinomas. Immunoreactive NK1 receptors are clearly confined to the plasma membrane and uniformly present on nearly all tumor cells. Development of this antibody allows efficient localization of NK1, and will facilitate identification of tumors with a sufficient receptor over-expression for diagnostic or therapeutic intervention.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Changes in substance P and NK1 receptor immunohistochemistry following human spinal cord injury.
PA3-301 was used in immunohistochemistry to study the immunohistochemical expression of substance P, NK1 and claudin-5 in traumatic spinal cord injury tissue
|Leonard AV,Manavis J,Blumbergs PC,Vink R||Spinal cord (52:17)||2014|
NK-1 receptor; NK-1R; NK1R; NKIR; TAC1R; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
NK1R; NKIR; SPR; TAC1R; TACR1