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|Tested species reactivity||Human , Rat , Insect|
|Published species reactivity||Mammals|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide derived from an internal sequence of the human, mouse, and rat NK1 receptor proteins|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva).
39-6100 was used in western blot to study the activation of brain stem PKA in vomiting least shrews treated with the emetic compound cyclophosphamide.
|Alkam T,Chebolu S,Darmani NA||European journal of pharmacology (722:156)||2014|
NK1R, NKIR, Tac1r, SPR, TAC1R
NK-1 receptor, NK-1R, SPR, neurokinin 1 receptor, substance p receptor, substance-P receptor, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor), TACR1, Neurokinin receptor 1, Nk1 tachykinin receptor, NK1R, TAC1R, Tachykinin 1 receptor, NKIR, Substance-P receptor, Neurokinin 1 receptor