Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous with Neuroligin 2.
Specificity of this antibody: Neuroligin 1, 2.
Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Neuroligin I; Neuroligin-1; Neuroligin-2; ortholog of human and rat neuroligin 2 NLGN2
Gene Aliases: 6330415N05Rik; BB179718; KIAA1070; KIAA1366; mKIAA1070; NL1; NL2; Nlg1; NLGN1; NLGN2
Molecular Function: cell adhesion molecule