Recommended positive controls: A431, H1299, HeLaS3, Raji.
Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (81%), Chicken (86%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C) and SEMA3F protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F), and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2
Gene Aliases: NP2; NPN2; NRP2; PRO2714; VEGF165R2
UniProt ID: (Human) Q7LBX6
Entrez Gene ID: (Human) 8828
Molecular Function: oxidoreductase