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Product Details
MA5-15551
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2E1
Immunogen
Purified recombinant fragment of human NKX2.5 expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_10982077
Product Specific Information
MA5-15551 targets NKX2.5 in indirect ELISA and WB applications, this antibody also shows reactivity with Human samples.
The MA5-15551 immunogen is purified recombinant fragment of human NKX2.5 expressed in E. Coli.
MA5-15551 detects NKX2.5 which has a predicted molecular weight of approximately 35kDa
Target Information
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac-specific homeobox; cardiac-specific homeobox 1; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; Homeobox protein CSX; Homeobox protein NK-2 homolog E; homeobox protein NKX 2-5; Homeobox protein Nkx-2.5; NK2 transcription factor related locus 5; NK2 transcription factor related, locus 5; NKX 2-5; Nkx-25; tinman paralog
Gene Aliases: CHNG5; CSX; CSX1; HLHS2; NKX2-5; NKX2.5; NKX2E; NKX4-1; VSD3
UniProt ID: (Human) P52952
Entrez Gene ID: (Human) 1482
Molecular Function:
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
heart looping
heart morphogenesis
outflow tract septum morphogenesis
cardiac conduction system development
bundle of His development
Purkinje myocyte differentiation
cardiac ventricle formation
right ventricular cardiac muscle tissue morphogenesis
ventricular trabecula myocardium morphogenesis
apoptotic process involved in heart morphogenesis
septum secundum development
proepicardium development
pulmonary myocardium development
transcription from RNA polymerase II promoter
adult heart development
positive regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
positive regulation of transcription via serum response element binding
positive regulation of sodium ion transport
negative regulation of myotube differentiation
hemopoiesis
cell differentiation
BMP signaling pathway
thyroid gland development
embryonic heart tube development
negative regulation of apoptotic process
sarcomere organization
positive regulation of neuron differentiation
positive regulation of heart contraction
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
positive regulation of cardioblast differentiation
ventricular cardiac myofibril assembly
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
atrial cardiac muscle cell development
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
pharyngeal system development
cardiac muscle cell proliferation
regulation of cardiac muscle cell proliferation
cardiac muscle contraction
canonical Wnt signaling pathway
positive regulation of transcription initiation from RNA polymerase II promoter
heart trabecula formation
ventricular septum morphogenesis
atrial septum morphogenesis
atrioventricular node cell development
atrioventricular node cell fate commitment
embryonic heart tube left/right pattern formation
negative regulation of canonical Wnt signaling pathway
regulation of cardiac conduction
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription cofactor activity
transcriptional activator activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
serum response element binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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