|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Fusion protein containing the N-terminal domain of the human Nkx3.1 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation.
35-9700 was used in western blot to study the roles of prostate tumor suppressor NKX3.1 in DNA repair and luminal cell differentiation
|Yang CC,Chung A,Ku CY,Brill LM,Williams R,Wolf DA||F1000Research (3:null)||2016|
|Human||Not Cited||NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity.||Bowen C,Stuart A,Ju JH,Tuan J,Blonder J,Conrads TP,Veenstra TD,Gelmann EP||Cancer research (67:455)||2007|
A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease.
35-9700 was used in immunohistochemistry to investigate the prognostic significance of a three-protein biomarker panel for prostate cancer
|Severi G,FitzGerald LM,Muller DC,Pedersen J,Longano A,Southey MC,Hopper JL,English DR,Giles GG,Mills J||Cancer medicine (3:1266)||2014|
TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells.
35-9700 was used in chip-sequencing to elucidate the metastatic process.
|Eide T,Ramberg H,Glackin C,Tindall D,Taskén KA||Cancer cell international (13:null)||2013|
||NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity.||Bowen C,Stuart A,Ju JH,Tuan J,Blonder J,Conrads TP,Veenstra TD,Gelmann EP||Cancer research (67:455)||2007|