Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-57809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Nkx6.1. Recombinant protein control fragment (Product #RP-97603).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644708
Product Specific Information
Immunogen sequence: PLGTHNPGGL KPPATGGLSS LGSPPQQLSA ATPHGINDIL SRPSM^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain. Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; NK homeo box, family 6, member A; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1
Gene Aliases: NKX6-1; NKX6.1; NKX6A
UniProt ID: (Human) P78426
Entrez Gene ID: (Human) 4825
negative regulation of transcription from RNA polymerase II promoter
neuron migration
transcription from RNA polymerase II promoter
smoothened signaling pathway
organ morphogenesis
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of axon extension
pancreas development
positive regulation of insulin secretion
response to nicotine
response to drug
type B pancreatic cell proliferation
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of glial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
detection of glucose
cellular response to cytokine stimulus
cellular response to peptide hormone stimulus
type B pancreatic cell maturation
positive regulation of type B pancreatic cell development
regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support