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Product Details
PA5-68213
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human Nkx6.1.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2692039
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain. Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Drosophila NK transcription factor related, gene family 6, locus 1; Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; homeodomain transcription factor Nkx6.1; NK homeo box, family 6, member A; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor related locus 1; NK6 transcription factor related, locus 1
Gene Aliases: NKX6-1; NKX6.1; Nkx61; NKX6A
UniProt ID: (Human) P78426, (Mouse) Q99MA9, (Rat) O35762
Entrez Gene ID: (Human) 4825, (Mouse) 18096, (Rat) 65193
Molecular Function:
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
neuron migration
transcription from RNA polymerase II promoter
smoothened signaling pathway
organ morphogenesis
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of axon extension
pancreas development
positive regulation of insulin secretion
response to nicotine
response to drug
type B pancreatic cell proliferation
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of glial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
detection of glucose
cellular response to cytokine stimulus
cellular response to peptide hormone stimulus
type B pancreatic cell maturation
positive regulation of type B pancreatic cell development
regulation of neuron migration
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
cell proliferation
central nervous system neuron differentiation
neurogenesis
cell differentiation
endocrine pancreas development
type B pancreatic cell development
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
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